Hao-Li Liu   (¼B¯E¿C)

 

Professor

Department of Electrical Engineering 

Chang Gung University, Taiwan 

Hao-Li Liu.jpg

 

 

Phone¡G886-3-2118800-3778

E-mail¡G haoliliu@mail.cgu.edu.tw

Research field¡GBiomedical electronics, therapeutic ultrasound, medical physics, medical imaging

Personal link¡G Google Scholar  PubMed Research Activities

 

Teaching :  Lecture material

 

Degree:  Ph.D. Institute of Electrical Engineering, National Taiwan University, Taiwan

 

 

 

 

Biography 

 

Hao-Li Liu received the Ph.D. degrees in Electrical Engineering in 2003 from the National Taiwan University, Taipei, Taiwan. In 2004-2005, He was the research fellow of the Department of Radiology, Brigham and Women¡¦s Hospital, Harvard Medical School, Boston, MA, USA. He is currently the Distinguished Professor of the Department of Electrical Engineering, Chang-Gung University, Taoyuan, Taiwan, and also the Adjunct Assistant Researcher of Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan. Dr. Liu is currently continuing research in ultrasound thermal therapy and its treatment planning/ simulation, ultrasound-induced blood brain barrier (BBB) disruption for brain drug delivery, ultrasound phased array design. Dr. Liu has published over 130 SCI papers, over 40 worldwide patents been filed in areas of biomedical use of therapeutic ultrasound. Dr. Liu is a member of IEEE and International Society of Therapeutic Ultrasound (ISTU).

 

Academic appointment:

¡P       2018- present, Distinguished Professor, Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan

¡P       2013 ¡V present, Adjunct Researcher, Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan

¡P       2012 ¡V 2015, Director, Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan

¡P       2011 ¡V present, Professor, Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan

¡P       2008 ¡V 2011, Associate Professor, Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan

¡P       2006 ¡V 2012, Adjunct Assistant Researcher, Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan

¡P       2005 ¡V 2008, Assistant Professor, Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan

¡P       2004 ¡V2005, Research Fellow, Focused Ultrasound Laboratory, Department of Radiology, Brigham & Women¡¦s Hospital, Harvard Medical School, MA, USA

 

Award:

¡P       2018, Distinguished Research Award (ªø©°¤j¾ÇÀu¨}±Ð®v¬ã¨s¼ú), Chang-Gung University.

¡P       2018, Acadamic Research Award, Ministry of Science and Technology (¬ì§Þ³¡³Ç¥X¬ã¨s¼ú), Taiwan.

¡P       2017, Future Technology Breakthrough Award, Ministry of Science and Technology (¬ì§Þ³¡¥¼¨Ó¬ì§Þ¬ð¯}¼ú), Taiwan.

¡P       2017, Lifetime Achievement Award, Albert Nelson Marquis Foundation.

¡P       2017, Excellent Technology Transfer Award(¬ì§Þ³¡³Ç¥X§ÞÂà°^Äm¼ú), Ministry of Science and Technology, Taiwan..

¡P       2015, The 12th National Innovation Award (¥Íµ¦·|²Ä12©¡°ê®a·s³Ð¼ú/¡u¾Ç¬ã·s³Ð¼ú¡vÃþ²Õ) awarded by the Institute for Biotechnology and Medicine Industry

¡P       2015, Distinguished Research Award (ªø©°¤j¾ÇÀu¨}±Ð®v¬ã¨s¼ú), Chang-Gung University.

¡P       2015, TienTe Lee Award (¥Ã«H§õ¤Ñ¼wÂåÃĬì§Þ¼ú), awarded by TienTe Lee Biomedical Foundation (¥Ã«H§õ¤Ñ¼wÂåÃÄ°òª÷·|) with the category of ¡u«C¦~ÂåÃĬì§Þ奬¡v, Taiwan.

¡P       2014, Taiwan Healthcare and Agricultural Biotech Industries Innovation and Excellence Awards, The Epoch Foundation(¥xÆW¥ÍÂåº[¥Í¹A¿ï¨q¤jÁÉ/¼ç¤O·s¨q¼ú­º¼ú)

¡P       2014, Distinguished Tech-Coop Award (ªø©°¤j¾ÇÀu¨}±Ð®v§Þ¦X¼ú), Chang-Gung University.

¡P       2013, Excellent Young Electrical Engineer Award (Àu¨q«C¦~¹q¾÷¤uµ{®v¼ú) from The Chinese Institute of Electrical Engineering, ROC (¤¤°ê¹q¾÷¤uµ{¾Ç·|).

¡P       2013, Frederick Lizzi Early Career Award, International Society for Therapeutic Ultrasound (ISTU).

¡P       2011, Distinguished Tech-Coop Award (ªø©°¤j¾ÇÀu¨}±Ð®v§Þ¦X¼ú), Chang-Gung University

¡P       2011, Wu Ta-You Memorial Award (¬ì§Þ³¡§d¤j·ß¥ý¥Í¬ö©À¼ú), National Science Council, Taiwan, 2011.

¡P       2010, Distinguished Research Award (ªø©°¤j¾ÇÀu¨}±Ð®v¬ã¨s¼ú), Chang-Gung University.

 

License¡G

¡P  Professional Electrical Engineer, Taiwan (¤¤µØ¥Á°ê¹q¾÷§Þ®v (¤K¤Q¤K¦~¹q¾÷§Þ®v°ª¦Ò¤Î®æ))

¡P  Medical Engineer, Taiwan (¤¤µØ¥Á°êÂå¾Ç¤uµ{®v )

 

 

 

 

 

Publication

 

 (A)SCI Journal

1.        CJ Lin, CY Lin, YT Lin, CY Huang, KC Wei, JC Chen, GJL Chen, HL Liu*, ¡§Microbubble-Facilitated Ultrasound Pulsation Promotes Direct £\-Synuclein Gene Delivery,¡¨ Biochemical and Biophysical Research Communications, Vol. 517, No. 1, pp. 77-83, 2019 (*³q°T§@ªÌ; IF = 2.466, 38/375 in¡§Biophysics¡¨).

2.        CH Wu, HL Liu, CT Ho, PH Hsu, CH Fan, CK Yeh, ST Kang, WS Chen, FN Wang, HH Peng, ¡§Monitoring of acoustic cavitation in microbubble-presented focused ultrasound exposure using gradient-echo magnetic resonance imaging,¡¨ Journal of Magnetic Resonance Imaging, Accepted, 2019 (IF=3.732, 26/125 in ¡§Radiology¡¨).

3.        CY Lin, CH Tsai, LY Feng, WY Chai, CJ Lin, CY Huang, KC Wei, CK Yeh, CM Chen, HL Liu, ¡§Focused Ultrasound-Induced Blood Brain-Barrier Opening Enhanced Vascular Permeability for GDNF Delivery in Huntington's Disease Mouse Model,¡¨ Brain Stimulation, Accepted, 2019 (*³q°T§@ªÌ; IF=6.919, 22/252 in ¡§Neuroscience¡¨).

4.        KT Chen, KC Wei and HL Liu*, ¡§Theranostic Strategy of Focused Ultrasound Induced Blood-Brain Barrier Opening for CNS Disease Treatment,¡¨ Frontiers in Pharmacology, Vol. 10, pp. 1-16, 2019 (*³q°T§@ªÌ; IF: 3.845, 59/261 in Pharmacology and Pharmacy).

5.        IC Lee, HJ Wu, HL Liu*, ¡§Dual-frequency ultrasound induces neural stem/progenitor cell differentiation and growth factor utilization by enhancing stable cavitation,¡¨ ACS Chemical Neuroscience, Vol. 10, pp. 1-18, DOI: 10.1021/acschemneuro.8b00483, 2018 (*³q°T§@ªÌ; IF: 3.861, 83/261 in ¡§Neuroscience¡¨)

6.        HC Tsai, CH Tsai, WS Chen, C Inserra, KC Wei, HL Liu*, "Safety evaluation of frequent application of microbubble-enhanced focused ultrasound blood-brain-barrier opening," Scientific Reports, Vol. 8, pp.1-13, 2018. (*³q°T§@ªÌ; IF=4.011, 15/64 in ¡§ Multidisciplinary Sciences¡¨)

7.        HL Liu*, CH Tsai, CK Jan, HY Chang, SM Huang, ML Li, W Qiu, H Zheng, ¡§Design and Implementation of a Dual-Transmit/Receive-Mode Therapeutic Ultrasound Phased Array System for Brain Therapy,¡¨ IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 65 , No. 10, Opp. 1756 ¡V 1767, 2018 (IF = 2.989, 6/31 in ¡§Acoustics¡¨)

8.        SM Huang, HL Liu, DW Li, and ML Li, ¡§Ultrasonic Nakagami Imaging of High-intensity Focused Ultrasound-Induced Thermal Lesions in Porcine Livers: Ex Vivo Study,¡¨ Ultrasonic Imaging, Accepted, 2018 (IF = 2.49, 9/31 in¡§Acoustics¡¨).

9.        PH Hsu, YT Lin, YH Chung, KJ Lin, LY Yang, TC Yen, and HL Liu*, "Focused Ultrasound-Induced Blood-Brain Barrier Opening Enhances GSK-3 Inhibitor Delivery for Amyloid-Beta Plaque Reduction," Scientific Reports, Vol. 8, pp.1-12, 2018. (*³q°T§@ªÌ; IF=4.011, 15/64 in ¡§ Multidisciplinary Sciences¡¨).

10.   CH Tsai, KT Chen, YX Lin, YC Lin, WS Chen, C Inserra, and HL Liu*, ¡§Acoustic Emission-Feedback Planar Ultrasound System for Localized Blood-Brain Barrier Opening Monitoring, ¡§ Journal of Medical and Biological Engineering, Vol. 39, No. 3, pp. 277-286, 2018 (*³q°T§@ªÌ; SCI IF = 1.306, 66/76 in ¡§Engineering, Biomedical¡¨).

11.   WY Chai, PC Chu, CH Tsai, CY Lin, HW Yang, HY Lai, HL Liu*, ¡§Image-Guided Focused-Ultrasound CNS Molecular Delivery: An Implementation via Dynamic Contrast-Enhanced Magnetic-Resonance Imaging,¡¨ Scientific Reports, 7;8(1):4151. doi: 10.1038/s41598-018-22571-8, 2018 (*³q°T§@ªÌ; IF=4.011, 15/64 in ¡§ Multidisciplinary Sciences¡¨). link

12.   ZH Zhou, SC Wu, MY Lin, J Fang, HL Liu*, and PH Tsui*, ¡§Three-dimensional visualization of ultrasound backscatter statistics by window-modulated compounding Nakagami imaging,¡¨ Ultrasonic Imaging, Vol. 40, No. 3, pp.171-189, 2018 (*³q°T§@ªÌ; IF = 2.49, 9/31 in¡§Acoustics¡¨). link

13.   Y Kung, C Lan, MY Hsiao, MK Sun, YH Hsu, APH Liao, WH Liao, HL Liu, C Inserra, WS Chen, ¡§Focused shockwave induced blood-brain barrier opening and transfection,¡¨ Scientific Reports, 2218, doi:10.1038/s41598-018-20672-y, 2018 (IF=4.011, 15/64 in ¡§ Multidisciplinary Sciences¡¨). link

14.   MT Tsai, JW Zhang, KC Wei, CK Yeh, HL Liu*, ¡§Assessment of temporary cerebral effects induced by focused ultrasound with optical coherence tomography angiography,¡¨ Biomedical Optics Express, Vol. 9, No. 2, pp.507-517, 2018. (IF = 3.91, 15/96 in ¡§Optics¡¨) link

15.   C Cornua, M Guédraa, J-C Béraa, HL Liu, WS Chen, C Inserraa, Ultrafast monitoring and control of subharmonic emissions of an unseeded bubble cloud during pulsed sonication, Ultrasonics Sonochemistry, Vol.42, pp. 697¡V703, 2018. (IF=7.279, 1/31 in ¡§Acoustics¡¨). link

16.   FCM Wu, WH Hsu, HL Liu, T Yonezawa,A Balcytis, S Juodkazis,and K Hatanaka, ¡§Photoacoustic signal enhancements from gold nano-colloidal suspensions excited by a pair of polarized time-delayed femtosecond pulses,¡¨ Optics Express, Vol. 25, pp. 19497-19507, 2017 (IF = 3.356, 19/96 in ¡§Optics¡¨).

17.   CH Fan, CY Lin, HL Liu*, and CK Yeh*, ¡§Ultrasound Targeted CNS Gene Delivery for Parkinson¡¦s Disease Treatment,¡¨ Journal of Controlled Release, Vol. 261, pp. 246-262, 2017 (*³q°T§@ªÌ; IF = 7.877, 9/256 in ¡§Pharmacology & Pharmacy¡¨).

18.   Lee, JC Yeh, CH Tsai, JT Yang, SL Lou, CJ Seak, CY Wang, KC Wei, HL Liu*, ¡§Improved thrombolytic effect with focused ultrasound and neuroprotective agent against acute carotid artery thrombosis in rat,¡¨ Scientific Reports, 7(1):1638. doi: 10.1038/s41598-017-01769-2., 2017. (*³q°T§@ªÌ; IF=4.122, 16/64 in ¡§ Multidisciplinary Sciences¡¨).  

19.   SK Wu, PC Chu, WY Chai, ST Kang, CH Tsai, CH Fan, CK Yeh, HL Liu*, ¡§Characterization of Different Microbubbles in Assisting Focused Ultrasound-Induced Blood-Brain Barrier Opening,¡¨ Scientific Reports, 7:46689. doi: 10.1038/srep46689., 2017. (*³q°T§@ªÌ; IF=4.122, 16/64 in ¡§ Multidisciplinary Sciences¡¨)

20.   PY Chen, CK Yeh, PH Hsu, CY Lin, CY Huang, KC Wei, HL Liu*, ¡§Drug-carrying Microbubbles as a Theranostic Tool in Convection-Enhanced Delivery for Brain Tumor Therapy,¡¨ Oncotarget, Vol. 8, No. 26, pp.42359-42371, 2017. (*³q°T§@ªÌ; IF = 5.168, 44/217 in "Oncology") link

21.   P Rwei, CSA Gong, LJ Luo, MB Lin, JY Lai*, HL Liu*, ¡§In vitro investigation of ultrasound-induced oxidative stress on human lens epithelial cells,¡¨ Biochemical and Biophysical Research Communications, Vol. 482, pp.954-960, 2017 (*³q°T§@ªÌ; IF = 2.466, 38/375 in ¡§Biophysics¡¨). link

22.   HH Peng, CH Wu, ST Kang, JW Zhang, HL Liu, WS Chen, CH Wang, CK Yeh, ¡§Real-Time Monitoring of Inertial Cavitation Effects of Microbubbles by Using MRI: In Vitro Experiments,¡¨ Magnetic Resonance in Medicine, Vol. 77, No. 1, pp.102-111, 2017 (IF=4.082, 19/126 in ¡§Radiology¡¨) link

23.   MT Tsai, JW Zhang, YH Liu, CK Yeh, KC Wei, and HL Liu*, ¡§Acoustic-actuated optical coherence angiography,¡¨ Optics Letters, Vol. 41, pp. 5813-5816, 2016 (*³q°T§@ªÌ; IF = 3.589, 14/96 in "Optics") link

24.   PC Chu, Wen-Yen Chai, CH Tsai, ST Kang, CK Yeh and HL Liu*, ¡§Focused Ultrasound-Induced Blood-Brain Barrier Opening: Association with Mechanical Index and Cavitation Index Analyzed by Dynamic Contrast-Enhanced Magnetic-Resonance Imaging,¡¨ Scientific Reports, 6:33264, doi: 10.1038/srep33264, 2016 (*³q°T§@ªÌ; IF=4.122, 16/64 in ¡§ Multidisciplinary Sciences¡¨). link

25.   FCP Masim, WH Hsu, CH Tsai, HL Liu, M Porta, MT Nguyen, T Yonezawa, A Balcytis, X Wang, S Juodkazis, and K Hatanaka, ¡§MHz-ultrasound generation by chirped femtosecond laser pulses from gold nano-colloidal dispersions,¡¨ Optics Express, Vol. 24, No. 15, pp. 24050-24059, 2016 (IF = 3.356, 19/96 in ¡§Optics¡¨) link

26.   FCP Masim, HL Liu, M Porta, T Yonezawa, A Balcytis, S Juodkazis, WH Hsu, and K Hatanaka, ¡§Enhanced photoacoustics from gold nano-colloidal suspensions under femtosecond laser excitation,¡¨ Optics Express, Vol. 24, No. 13, pp.14781-14792, 2016 (IF = 3.356, 19/96 in ¡§Optics¡¨) link

27.   J Xia, PH Tsui, HL Liu*, ¡§Low-Pressure Burst-Mode Focused Ultrasound Wave Reconstruction and Mapping for Blood-Brain Barrier Opening: A Preclinical Examination,¡¨ Scientific Reports, 6:27939, doi:10.1038/srep27939., 2016 (*³q°T§@ªÌ; IF=4.122, 16/64 in ¡§ Multidisciplinary Sciences¡¨). link

28.   YW Chen, TY Liu, PH Chang, PH Hsu, HL Liu, HC Lin, SY Chen, ¡§A theranostic nrGO@MSN-ION nanocarrier developed to enhance the combination effect of sonodynamic therapy and ultrasound hyperthermia for treating tumor,¡¨ Nanoscale, Vol. 8, No. 25, pp.12648-57, 2016. (IF = 7.233, 25/165 in ¡§Chemistry, Multiplidiciplinary¡¨)

29.   CY Lin, HY Hsieh, CM Chen, SR Wu, CH Tsai, CY Huang, MY Hua, KC Wei, CK Yeh, and HL Liu*, "Non-invasive, Neuron-Specific Gene Therapy by Focused Ultrasound-Induced Blood-Brain Barrier Opening in Parkinson¡¦s Disease Mouse Model", Journal of Controlled Release, Vol. 235, pp. 72-81, 2016 (*³q°T§@ªÌ; IF = 7.877, 9/256 in ¡§Pharmacology & Pharmacy¡¨) link

30.   SS Li, CW Lin, KC Wei, CY Huang, PH Hsu, HL Liu, YJ Lu, SC Lin, HW Yang*, CCM Ma*, ¡§Non-invasive screening for early Alzheimer's disease diagnosis by a sensitively immunomagnetic biosensor¡¨, Scientific Reports, 6:25155. doi:10.1038/srep25155., 2016 (IF=5.228, 7/63 in ¡§ Multidisciplinary Sciences¡¨). link

31.   CH Fan, YH Cheng, CY Ting, YJ Ho, PH Hsu, HL Liu*, CK Yeh*, ¡§Ultrasound/Magnetic Targeting with SPIO-DOX-Microbubble Complex for Image-Guided Drug Delivery in Brain Tumors,¡¨ Theranostics, Vol. 6, No. 10, pp.1542-1556, 2016 (*³q°T§@ªÌ; IF = 8.537, 8/128 in ¡§Medicine, Research and Experimental¡¨). link

32.   MT Tsai, IC Lee, ZF Lee, HL Liu, YC Choia, CC Wang, JD Lee1*, ¡§In vivo evaluation of temporal effects and drug delivery induced by transdermal microneedles with optical coherence imaging,¡¨ Biomedical Optics Express, Vol. 7, No. 5, pp. 1865-1876, 2016 (IF = 3.482, 15/96 in ¡§Optics¡¨). link

33.   HL Liu, PH Hsu, CY Lin, CW Huang, WY Chai, PC Chu, CY Huang, PY Chen, LY Yang, JS Kuo, KC Wei*, ¡§Focused Ultrasound Enhances CNS Delivery of Bevacizumab for Malignant Glioma Treatment,¡¨ Radiology, Vol. 281, pp. 99-108, 2016 (IF=7.469, 4/126 in¡§Radiology¡¨). link

34.   CH Tsai, JW Zhang, YY Liao, HL Liu*, ¡§Real-time monitoring of focused ultrasound blood-brain barrier opening via subharmonic acoustic emission detection: Implementation of confocal dual-frequency piezoelectric transducers,¡¨ Physics in Medicine and Biology, Vol. 61, pp. 2926-2946, 2016 (*³q°T§@ªÌ; IF = 2.665, 27/77 in ¡§Engineering, Biomedical¡¨) link

35.   CH Fan, CY Ting, CY Lin, HL Chan, YC Chang, YY Chen, HL Liu*, and CK Yeh*, ¡§Noninvasive, Targeted, and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson's Disease,¡¨ Scientific Reports, 6:19579. doi:10.1038/srep19579, 2016 (*³q°T§@ªÌ; IF=4.122, 16/64 in ¡§ Multidisciplinary Sciences¡¨). link

36.   PC Chu**, HL Liu**, HY Lai, CY Lin, HC Tsai, YC Pei, "Neuromodulation accompanying focused ultrasound-induced blood-brain barrier opening," Scientific Reports, Vol. 5: 15477, 2015 (**Equal Contribution; IF=5.228, 7/63 in ¡§ Multidisciplinary Sciences¡¨). link

37.   PY Chen, KC Wei, HL Liu*, ¡§Neural Immune Modulation and Immunotherapy Assisted by Focused Ultrasound Induced Blood-Brain Barrier Opening", Human Vaccines & Immunotherapeutics, Vol. 11, no. 10, accepted, 2014 (*³q°T§@ªÌ; IF = 2.157, 79/161 in ¡§Biotechnology & Applied Microbiology¡¨). link

38.   CY Lin, HY Hsieh, WG Pitt, CY Huang, IC Tseng, CK Yeh, KC Wei, HL Liu*, ¡§Focused Ultrasound-Induced Blood-Brain Barrier Opening for Non-Viral, Non-invasive, and Targeted Gene Delivery,¡¨ Journal of Controlled Release, Vol. 212, pp.1-9, 2015 (*³q°T§@ªÌ; IF = 7.877, 9/256 in ¡§Pharmacology & Pharmacy¡¨) link (Selected as ¡§Cover story¡¨ of the issue)

1.        AH Liao, HY Chou, YL Hsieh, SC Hsu, KC Wei, and HL Liu*, ¡§Enhanced Therapeutic Epidermal growth factor receptor (EGFR) Antibody Delivery via Pulsed Ultrasound with Targeting Microbubbles for Glioma Treatment,¡¨ Journal of Medical and Biological Engineering, Vol. 1, pp. 1-9, Eng. DOI 10.1007/s40846-015-0032-9, 2014 (SCI IF = 1.211, 55/76 in ¡§Engineering, Biomedical¡¨). link (Selected as ¡§The paper of the year in JMBE¡¨)

2.        PY Chen, HY Hsieh, CY Huang, CY Lin, KC Wei, and HL Liu*, ¡§Focused Ultrasound-Induced Blood-Brain Barrier Opening to Enhance Interleukin-12 Delivery for Brain Tumor Immunotherapy: A Preclinical Feasibility Study,¡¨ Journal of Translational Medicine, Vol. 13, No. 93, pp. 1-12, 2015 (*Corresponding author; IF = 4.197, 28/128 in ¡§Medicine, Res. & Exp¡¨). link

3.        CH Fan, CY Ting, YC Chang, KC Wei, HL Liu*, and CK Yeh*, "Drug-loaded Bubbles with Matched Focused Ultrasound Excitation for Concurrent Blood-Brain Barrier Opening and Brain-Tumor Drug Delivery," Acta Biomaterialia, Vol. 15, pp. 89¡V101, 2015 (*Corresponding author; IF = 6.383, 3/78 in ¡§Engineering, Biomedical¡¨) link

4.        HY Huang**, HL Liu**, PH Hsu, CS Chiang, CH Tsai, HS Chi, SY Chen, and YY Chen*, ¡§Multitheragnostic Nanobubble System to Induce Brain-Blood Barrier Disruption with Magnetically Guided Focused Ultrasound,¡¨ Advanced Materials, Vol. 27, pp. 655-661, 2015 (**Equal Contribution; IF=21.95, 5/165 in ¡§Chemistry, Multidisciplinary¡¨) link

5.        HL Liu*, CY Huang, JY Chen, HYJ Wang, PY Chen, and KC Wei, ¡§Pharmacodynamic and Therapeutic Investigation of Focused Ultrasound-induced Blood-Brain Barrier Opening for Enhanced Temozolomide Delivery in Glioma Treatment,¡¨ PLoS ONE, Vol. 9, No. 12, e114311, 2014 (SCI IF = 2.766, 15/64 in ¡§Multidisciplinary Sciences¡¨) link (Highlight by Neurosurgery)

6.        KJ Chen, EY Chaung, SP Wey, KJ Lin, F Cheng, CC Lin, HL Liu, HW Tseng, CP L, MC W, CM Liu, and HW Sung, "Hyperthermia-Mediated Local Drug Delivery by a Bubble-Generating Liposomal System for Tumor-Specific Chemotherapy,¡¨ ACS Nano, Vol. 8, No. 5, pp. 5105-5115, 2014 (IF=13.7, 10/163 in ¡§Chemistry, Multidisciplinary¡¨). link

7.        MT Tsai, FY Chang, CK Lee, CS Gong, YX Lin, JD Lee, CH Yang, HL Liu*, ¡§Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography,¡¨ Biomedical Optics Express. Vol. 5, No. 7, pp. 2009-22, 2014. (*Corresponding author; IF = 3.482, 15/96 in ¡§Optics¡¨). link

8.        CH Fan, WH Lin, CY Ting, WY Chai, TC Yen, HL Liu* and CK Yeh*, ¡§Contrast-Enhanced Ultrasound Imaging for the Detection of Focused Ultrasound-Induced Blood-Brain Barrier Opening,¡¨ Theranostics, Vol. 4, No. 10, pp. 1014-1025, 2014 (*Corresponding author; IF = 8.537, 8/128 in ¡§Medicine, Research and Experimental¡¨). link

9.        WY Chai, PC Chu, MY Tsai, YC Lin, JJ Wang, KC Wei, YY Wai and HL Liu*, ¡§Magnetic-Resonance Imaging for Kinetic Analysis of Permeability Changes during Focused Ultrasound-Induced Blood-Brain Barrier Opening and Brain Drug Delivery,¡¨ Journal of Controlled Release, Vol. 192, pp.1-9, 2014 (SCI IF = 7.877, 9/256 in ¡§Pharmacology & Pharmacy¡¨) link

10.   J Xia, Q Li,PY Chen, Z Zhou,CY Wang, HL Liu, J Teng, and PH Tsui, "Considering Angle Selection When Using Ultrasound Electrode Displacement Elastography to Evaluate Radiofrequency Ablation of Tissues," BioMed Research International, Volume 2014, ID 764320, 2014 (IF = 2.476, 81/161 in "Biotech. and App. Microbiology")

11.   CH Fan**, HL Liu**, CY Ting, YH Lee, CY Huang, YJ Ma, KC Wei, TC Yen and CK Yeh, ¡§Submicron-Bubble-Enhanced Focused Ultrasound for Blood¡VBrain Barrier Disruption and Improved CNS Drug Delivery,¡¨ PLoS ONE, Vol.9, No. 5, e96327, 2014 (**Equal contribution, SCI IF = 2.766, 15/64 in ¡§Multidisciplinary Sciences¡¨) link

12.   X Geng, Z Zhou, Q Li, S Wu, CY Wang, HL Liu, CC Chuang, and PH Tsui, ¡§Comparison of ultraosund temperature imaging with infrared thermometry during radio frequency ablation,¡¨ Japanese Journal of Applied Physics, Vol. 53, No. 4, pp. 047001, 2014 (IF = 1.122, 97/145 in Phycis, Applied)

13.   HL Liu*, CK Jan, PC Chu, JC Hong, PY Lee, JD Hsu, CC Lin, CY Huang, PY Chen, and KC Wei*, ¡§Design and Experimental Evaluation of a 256-Channel Dual-Frequency Ultrasound Phased-Array System for Transcranial Blood-Brain Barrier Opening and Brain Drug Delivery,¡¨ IEEE Transactions on Biomedical Engineering, Vol. 61, No. 4, pp.1350-1360, 2014 (IF=4.288, 9/78 in ¡§Engineering, Biomedical¡¨). link

14.   HL Liu, CH Fan, CY Ting, and CK Yeh, "Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors" Theranostics, Vol. 4, No. 4, pp.432-444, 2014 (IF = 8.537, 8/128 in ¡§Medicine, Research and Experimental¡¨). link

15.   HW Yang, CY Huang, CW Lin, HL Liu, CW Huang, SS Liao, PY Chen, PW Hsu, YJ Lu, KC Wei, CCM Ma, ¡§Gadolinium-functionalized nanographene oxide as a nanocarrier for combined drug and microRNA delivery and magnetic resonance imaging,¡¨ Biomaterials, Vol., 35, No. 6534-42, 2014 (IF = 8.806, 1/78 in ¡§Engineering, Biomedical¡¨). link

16.   JJ Xia, Q Li, HL Liu, WS Chen and PH Tsui, "An Approach for the Visualization of Temperature Distribution in Tissues According to Changes in Ultrasonic Backscattered Energy," Computational and Mathematical Methods in Medicine, Volume 2013, Article ID 682827 (IF = 0.766).

17.   YW Huang, SH Hu, SY Hung, CS Chiang, HL Liu, TL Chiou, HY Lai, YY Chen, "SPIO Nanoparticle-Stabilized Nanobubbles with MR/US Dual-Modality Imaging and HIFU-triggered Release Drug for in-vivo Therapy," Journal of Controlled Release, Vol. 172, pp.118-127, 2013 (IF = 7.786, 10/256 in "Chemistry, Multidisciplinary). link

18.   HW Yang, YJ Lu, KJ Lin, SC Hsu, CY Huang, SH She, HL Liu, MC Xiao, SP Wey, PY Chen, TC Yen, KC Wei, CCM Ma, "EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy, " Biomaterials, Vol. 34, No. 29, pp. 7204-7214, 2013 IF = 8.806, 1/78 in ¡§Engineering, Biomedical¡¨). link

19.   MT Tsai, CK Lee, KM Lin, YX Lin, TH Lin, TC Chang and HL Liu*, "Quantitative Observation Evaluation of Focused Ultrasound Induced Vascular Leakage and Deformation after Focused Ultrasound Treatment Exposure via by using Fluorescein Angiography and Optical Coherence Tomography," Journal of Biomedical Optics, Vol.18, No. 10, pp.101307, 2013 (IF=2.53, 30/92 in ¡§Optics¡¨). link

20.   CY Wang, TS Yeh, XN Geng, HL Liu, and PH Tsui, "Monitoring Radiofrequency Ablation with Ultrasound Nakagami Imaging," Medical Physics, Vol.40, No.7, pp.072901, 2013. (IF=2.884, 36/126 in ¡§Radiology¡¨). 

21.   H.W. Yang, M.Y. Hua, T.L. Hwang, K.J. Lin, C.Y. Huang, R.Y. Tsai, C.C.M. Ma, P.H. Hsu, S.P. Wey, P.W. Hsu, P.Y. Chen, Y.C. Huang, Y.J. Lu, T.C. Yen, L.Y. Feng, C.W. Lin, H.L. Liu*, K.C. Wei*. ¡§Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide,¡¨ Advanced Materials, Vol. 25, No. 26, pp.3605-3611, 2013. (*Corresponding author; IF=21.95, 5/165 in ¡§Chemistry, Multidisciplinary¡¨). link

22.   HW Yang, HL Liu**, ML Li, IW Hsi, CT Fan, CY Huang, YJ Lu, MY Hua, HY Chou, JW Liaw, CCM Ma and KC Wei, "Magnetic gold-nanorod/ PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy," Biomaterials, Vol. 34, pp.5651-5660, 2013. (**¦@¦P²Ä¤@§@ªÌ; IF = 8.806, 1/78 in ¡§Engineering, Biomedical¡¨). link

23.   PC Chu, WY Chai, HY Hsieh, JJ Wang, SP Wey, CY Huang, KC Wei and HL Liu*, "Pharmacodynamic Analysis of Magnetic Resonance Imaging-Monitored Focused Ultrasound-Induced Blood-Brain Barrier Opening for Drug Delivery to Brain Tumors," BioMed Research International, Vol. 2013, pp. 627496, 2013 (*³q°T§@ªÌ; IF = 2.476, 81/161 in "Biotech. and App. Microbiology").link

24.   KC Wei, PC Chu, HYJ Wang, CY Huang, PY Chen, HC Tsai, YJ Lu, IC Tseng, PY Lee, TC Yen, and HL Liu*, "Focused Ultrasound-induced Blood¡VBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment: A Preclinical Study, " PLoS ONE, Vol. 8, No. 3, pp. e58995, 2013 (*³q°T§@ªÌ; SCI IF = 2.766, 15/64 in ¡§Multidisciplinary Sciences¡¨) link

25.   C-H Fan, C-Y Ting, H-J Lin, C-H Wang, H-L Liu*, T-C Yen, C-K Yeh*, "SPIO-Conjugated, Doxorubicin-Loaded Microbubbles for Concurrent MRI and Focused-Ultrasound Enhanced Brain-Tumor Drug Delivery," Biomaterials, Vol. 34, pp. 3706-3715, 2013 (*¦@¦P³q°T§@ªÌ; IF = 8.806, 1/78 in ¡§Engineering, Biomedical¡¨) link

26.   P-H Hsu, K-C Wei, C-Y Huang, C-J Wen, T-C Yen, C-L Liu, Y-T Lin, J-C Chen, C-R Shen, and H-L Liu*, "Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound, " PLoS ONE, Vol. 8, No. 2, pp. e57682, 2013 (*³q°T§@ªÌ; SCI IF = 3.234, 8/56 in " Multidisciplinary Sciences ") link

27.   K.J. Chen, H.F. Liang, H.L. Chen, Y.C. Wang, P.Y. Cheng, H.L. Liu, Y.N. Xia, H.W. Sung, "A Thermoresponsive Bubble-Generating Liposomal System for Triggering Localized Extracellular Drug Delivery", ACS Nano, Vol. 7, No. 1, pp. 438-446, 2013 (IF=13.334, 8/163 in ¡§Chemistry, Multidisciplinary¡¨). link

28.   C-H Fan, C-Y Ting, H-L Liu*, C-Y Huang, H-Y Hsieh, T-C Yen, K-C Wei, C-K Yeh, "Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment, " Biomaterials, Vol. 34, pp. 2142-2155, 2013 (*¦@¦P³q°T§@ªÌ; IF = 8.806, 1/78 in ¡§Engineering, Biomedical¡¨). link

29.   K-C Wei, H-C Tsai, Y-J Lu, H-W Yang, M-Y Hua, M-F Wu, P-Y Chen, C-Y Huang, T-C Yen, and H-L Liu*, ¡§Neuronavigation-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening: A Preliminary Study in Swine,¡¨ American Journal of Neuroradiology, Vol. 34, No. 1, pp. 115-120, 2013. (IF=3.55, 24/124 in ¡§Radiology¡¨) link

30.   H-L Liu, H-Y Hsieh, L-A Lu, C-W Kang, M-F Wu and C-Y Lin, "Low-Pressure Pulsed Focused Ultrasound with Microbubbles Promotes an Anticancer Immunological Response," Journal of Translational Medicine, Vol. 10: 221, 2012 (IF = 3.786, 30/128 in "Medicine, Res. & Exp") link

31.   H-W Yang, M-Y Hua, K-J Lin, S-P Wey, R-Y Tsai, S-Y Wu, Y-C Lu, H-L Liu, Tony Wu, Y-H Ma, ¡§Bioconjugation of recombinant tissue plasminogen activator to magnetic nanocarriers for targeted thrombolysis,¡¨ International Journal of Nanomedicine, Vol. 7, pp. 1¡V11, 2012 (IF = 4.3, 26/83 in "Nanoscience & Nanotechnology").

32.   H-W Yang, M-Y Hua, H-L Liu, C-Y Huang, K-C Wei, ¡§Potential of magnetic nanoparticles for targeted drug delivery.¡¨ Nanotechnology, Science and Applications, Vol. 5, pp. 73-86, 2012 (SCI).

33.   A-H Liao, Y-K Li, W-J Lee, M-F Wu, H-L Liu, and M-L Kuo, ¡§Estimating the Delivery Efficiency of Drug-Loaded Microbubbles in Cancer Cells with Ultrasound and Bioluminescence Imaging,¡¨ Ultrasound in Medicine and Biology, Vol. 38, No. 11, pp. 1938¡V1948, 2012 (IF=2.645, 7/32 in ¡§Acoustics¡¨).

34.   P-H Liao, H-H Yang, P-T Chou, M-H Wang, P-C Ju, H-L Liu, and L-K Chen, "Sufficient virus-neutralizing antibody in the central nerve system improves the survival of rabid rats," Journal of Biomedical Sciences, Vol. 19: 61, 2012 (IF = 1.98)

35.   Y-H Ma, S-Y Chen, S-J Tu, H-W Yang, H-L Liu, ¡§Manipulation of magnetic nanoparticle retention and hemodynamic consequences in microcirculation: assessment by laser speckle imaging,¡¨ International Journal of Nanomedicine, Vol. 7, pp. 1¡V11, 2012 (IF = 4.3, 26/83 in "Nanoscience & Nanotechnology")

36.   C-J Ke, Y-J Lin, Y-C Hua, W-L Chiang, K-J Chen, W-C Yang, H-L Liu, C-C Fu, H-W Sung, ¡§Multidrug release based on microneedle arrays filled with pH-responsive PLGA hollow microspheres,¡¨ Biomaterials, Vol. 33, No. 20, pp. 5156-5165, 2012. (IF = 8.806, 1/78 in ¡§Engineering, Biomedical¡¨).

37.   A-H Liao, H-L Liu**, C-H Su, M-Y Hua, H-W Yang, Y-T Weng, P-H Hsu, S-M Huang, S-Y Wu, H-El Wang, T-C Yen and P-C Li, ¡§Paramagnetic Perfluorocarbon-Filled Albumin-(Gd-DTPA) Microbubbles for the Induction of Focused-Ultrasound-Induced Blood¡VBrain Barrier Opening and Concurrent MR and Ultrasound Imaging,¡¨ Physics in Medicine and Biology, Vol. 57, pp.2787-2802, 2012 (**¦@¦P²Ä¤@§@ªÌ; IF = 2.665, 27/77 in ¡§Engineering, Biomedical¡¨) link

38.   P-H Tsui, Y-C Shu, W-S Chen, H-L Liu, I-T Hsiao, and Y-T Chien, "Ultrasound temperature estimation based on probability variation of backscatter data", Medical Physics, Vol. 39, No. 5, pp. 2369-2385, 2012 (IF=2.884, 36/126 in ¡§Radiology¡¨). 

39.   P-H Wang**, H-L Liu**, P-H Hsu, C-R C Wang, P-Y Chen, K-C Wei, T-C Yen, and M-L Li, "Gold-nanorod contrast-enhanced photoacoustic micro-imaging of focused- ultrasound induced blood-brain barrier opening in a rat model", Journal of Biomedical Optics, Vol. 17, No. 6, pp. 061222, 2012 (**¦@¦P²Ä¤@§@ªÌ; IF= 2.556, 21/90 in ¡§Optics¡¨). link

40.   C-H Fan, H-L Liu, C-Y Huang, Y-J Ma, T-C Yen, C-K Yeh, ¡§Detection of intracerebral hemorrhage and transient blood-supply shortage in focused ultrasound-induced blood-brain-barrier disruption by ultrasound imaging,¡¨ Ultrasound in Medicine and Biology, Vol. 38, No. 8, pp. 1372¡V1382, 2012 (IF=2.645, 7/32 in ¡§Acoustics¡¨). link

41.   P-H Tsui, Y-T Chien, H-L Liu, Y-C Shu, W-S Chen, ¡§Using ultrasound CBE imaging without echo shift compensation for temperature estimation,¡¨ Ultrasonics, Vol. 52, No. 7, pp. 925-935, 2012. (IF=1.954, 8/32 in ¡§Acoustics¡¨)

42.   H-W Yang**, M-Y Hua**, H-L Liu**, R-Y Tsai, S-T Pang, P-H Hsu, H-J Tang, T-C Yen, C-K Chuang, ¡§An epirubicin-conjugated nanocarrier with MRI function to overcome lethal multidrug-resistant bladder cancer,¡¨ Biomaterials, Vol. 33, pp. 3919-3930, 2012. (**¦@¦P²Ä¤@§@ªÌ; IF = 8.806, 1/78 in ¡§Engineering, Biomedical¡¨). link

43.   H-W Yang**, M-Y Hua**, H-L Liu**, R-Y Tsai, C-K Chuang, P-C Chu,P-Y Wu, Y-H Chang, H-C Chuang, K-J Yu, and S-T Pang, ¡§Cooperative dual-activity targeted nanomedicine for specific and effective prostate cancer therapy¡¨, ACS Nano, Vol.6, No. 2, pp1795-1805, 2012 (**¦@¦P²Ä¤@§@ªÌ; IF=13.334, 8/163 in ¡§Chemistry, Multidisciplinary¡¨¡¨). link

44.   Y-C Lin, T-H Chan, C-Y Chi, S-H Ng, H-L Liu, K-C Wei, Y-Y Wei, C-C Wang, J-J Wang, ¡§Blind Estimation of Arterial Input Function in Dynamic Contrast-Enhanced MRI using Purity Maximization,¡¨ Magnetic Resonance in Medicine, Vol. 68, No. 5, pp. 1439-1449, 2012 (IF=4.082, 19/126 in ¡§Radiology¡¨)

45.   H-L Liu, H-W Yang, M-Y Hua, and K-C Wei, ¡§Enhanced Therapeutic Agent Delivery via MRI-Monitored Focused Ultrasound Blood-Brain Barrier Disruption for Brain Tumor Treatment: An Overview of the current Preclinical Status,¡¨ Neurosurgical Focus, Vol. 32, No. 1, E4, 2012 (IF = 3.139, 39/196 in ¡§Surgery¡¨). link

46.   C-Y Ting, C-H Fan, H-L Liu*, C-Y Huang, H-Y Hsieh, T-C Yen, K-C Wei, C-K Yeh*, ¡§Concurrent blood-brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment,¡¨ Biomaterials, Vol. 33, pp. 704-712, 2012 (*Co-corresponding author, IF = 8.806, 1/78 in ¡§Engineering, Biomedical¡¨). link

47.   M-T Tsai, T-D Chi, H-L Liu, F-Y Chang, C-H Yang, C-K Lee, and C-C Yang, ¡§Microvascular imaging using swept-source optical coherence tomography with single-channel acquisition,¡¨ Appl. Phys. Express, Vol. 4, pp.097001-3, 2011 (IF =2.365, 21/125 in ¡§Physics, Applied¡¨).

48.   W-S Chen, H-L Liu, Y.S. Tung, J.C. Wang, Y.H. Ding, C.K. Jan, ¡§Reducing lesion aberration by dual-frequency focused ultrasound ablations,¡¨ International Journal of Hyperthermia, Vol. 27, No. 7, pp. 637-647, 2011 (IF=2.645, 37/125in ¡§Radiology¡¨).

49.   C-J Ke, T-Y Su, H-Chen, H-L Liu, W-L Chiang, P-C Chu, Y Xia, H-W Sung, ¡§Smart Multifunctional Hollow Microspheres for the Quick Release of Drugs in Intracellular Lysosomal Compartments,¡¨ Angewandte Chemie International Edition, Vol. 50, No. 35, pp. 8086 ¡V 8089, 2011 (IF = 11.994, 13/157 in ¡§Chemistry, Multidisciplinary¡¨)

50.   M-Y Hua**, H-W Yang**, H-L Liu**, R-Y Tsai, S-T Pang, K-L Chuang, Y-S Chang, T-L Hwang, Y-H Chang, H-C Chuang, C-K Chuang, ¡§Superhigh-magnetization nanocarrier as a doxorubicin delivery platform for magnetic targeting therapy,¡¨ Biomaterials, Vol. 32, pp. 8999-9910, 2011 (**¦@¦P²Ä¤@§@ªÌ, IF = 8.806, 1/78 in ¡§Engineering, Biomedical¡¨). link

51.   J-J Wang , W-Y Lin, C-S Lu, Y-H Weng, S-H Ng , C-H Wang , H-L Liu, R-H Hsieh , Y-L Wan, and Y-Y Wai, ¡§Parkinson Disease_Diagnostic Utility of Diffusion Kurtosis Imaging,¡¨ Radiology, Vol. 261, No. 1, pp. 210-217 (IF=7.469, 4/126 in¡§Radiology¡¨).

52.   H-L Liu, P-Y Chen, H-W Yang, J-S Wu, I-C Tseng, Y-J Ma, C-Y Huang, H-C Tsai,  S-M Chen, Y-J Lu, C-Y Huang, M-Y Hua, Y-H Ma, T-C Yen and K-C Wei, ¡§In Vivo MR Quantification of Superparamagnetic Iron Oxide Nanoparticle Leakage During Low-frequency-ultrasound¡Vinduced Blood¡VBrain Barrier Opening In Swine,¡¨ Journal of Magnetic Resonance Imaging, Vol. 34, No. 12, pp. 1313-1324, 2011 (IF=3.083, 23/125 in ¡§Radiology¡¨). link

53.   H-W Yang**, M-Y Hua**, H-L Liu**, C-Y Huang, R-Y Tsai, Y-J Lu, J-Y Chen, H-J Tang, H-Y Hsien, Y-S Chang, T-C Yen, P-Y Chen and K-C Wei, ¡§Self-protecting core-shell magnetic nanoparticles for targeted, traceable, long half-life delivery of BCNU to gliomas,¡¨ Biomaterials, Vol. 32, pp. 6523-6532, 2011 (**¦@¦P²Ä¤@§@ªÌ, IF = 8.806, 1/78 in ¡§Engineering, Biomedical¡¨). link

54.   W-S Chen, C-C Shen, C-T Ko, C-H Cheng, H-L Liu, M-C Ho, C-N Chen, C-K Yeh, ¡§Single-Element Ultrasound Transducer for Combined Vessel Localization and Ablation,¡¨ IEEE Trans. Ultrason. Ferroelectrics Freq. Contr., Vol. 58, No. 4, pp. 766-775, 2011 (IF = 1.512, 10/31 in ¡§Acoustics¡¨)

55.   H-L Liu, M-L Li, P-H Tsui, M-S Lin, S-M Huang, and J Bai, ¡§An Unified Approach to Combine Temperature Estimation and Elastography for Thermal Lesion Determination in Focused Ultrasound Thermal Therapy,¡¨ Physics in Medicine and Biology, Vol. 56, pp. 169-186, 2011. (IF = 2.665, 27/77 in ¡§Engineering, Biomedical¡¨) link

56.   M-Y Hua**, H-L Liu**, H-W Yang, P-Y Chen, R-Y Tsai, C-Y Huang, I-C Tseng, L-A Lyu, C-C Ma, H-J Tang, T-C Yen, K-C Wei, ¡§The effectiveness of a magnetic-nanoparticle-based delivery system for BCNU in the treatment of gliomas,¡¨ Biomaterials, Vol. 32, pp. 512-523, 2011 (**¦@¦P²Ä¤@§@ªÌ, IF = 8.806, 1/78 in ¡§Engineering, Biomedical¡¨). link

57.   H-L Liu, S-M Huang, and M-L Li, ¡§High frame rate ultrasound monitoring of high intensity focused ultrasound induced temperature changes: a novel asynchronous approach,¡¨ Medical Physics, Vol. 37, No. 11, pp. 5921-5928, 2010 (IF=2.884, 36/126 in ¡§Radiology¡¨). link

58.   H-L Liu, M-Y Hua, H-W Yang, C-Y Huang, P-C Chu, J-S Wua, I-C Tseng, J-J Wang, T-C Yen, P-Y Chen, and K-C Wei, ¡§Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain,¡¨ Proceedings of National Academy of Science USA, Vol. 107, No. 34, pp.15205-15210, 2010 (IF=9.504, 5/74 in ¡§Multidisciplinary sciences¡¨). link

59.   K-C Ju and H-L Liu, ¡§Zero-crossing-tracking technique for noninvasively ultrasonic temperature estimation,¡¨ Journal of Ultrasound in Medicine, Vol. 29, pp.1607¡V1615, 2010 (IF=1.402, 13/31 in ¡§Acoustics¡¨).

60.   P-Y Chen**, H-L Liu**, M-Y Hua, H-W Yang, C-Y Huang, P-C Chu, L-A Lyu, H-C Tsai, S-M Chen, Y-J Lu, J-J Wang, T-C Yen, Y-H Ma, T. Wu, J-P Chen, J-I Chuang, J-W Shin, C. Hsueh, and K-C Wei, ¡§Novel Magnetic/Ultrasound Focusing System Enhances Nanoparticle Drug Delivery for Glioma Treatment,¡¨ Neuro-oncology, Vol. 12, No. 10, pp.1050-1060, 2010 (**¦@¦P²Ä¤@§@ªÌ, IF=9.384, 15/194 in ¡§Clinical Neurology¡¨). link

61.   H-L Liu, M-Y Hua, P-Y Chen, P-C Chu, C-H Pan, H-W Yang, C-Y Huang, J-J Wang,  T-C Yen and K-C Wei, ¡§Blood¡VBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatment,¡¨ Radiology, Vol. 255, No. 2, pp. 415-425, 2010 (IF=7.469, 4/126 in¡§Radiology¡¨) link

62.   H-L Liu, C-L Hsu, S-M Huang and Y-W Hsi, ¡§Focal Beam Distortion and Treatment Planning for Transrib Focused Ultrasound Thermal Therapy: A Feasibility Study Using a Two-dimensional Ultrasound Phased Array,¡¨ Medical Physics, Vol. 37, No. 2, pp. 848-860, 2010 (IF=2.884, 36/126 in ¡§Radiology¡¨).link

63.   H-L Liu, C-H Pan, C-Y Ting and M-J Hsiao, ¡§Opening of the Blood-Brain Barrier By Low-Frequency (28-kHz) Ultrasound: A Novel Pinhole-Assisted Mechanical Scanning Device,¡¨ Ultrasound in Medicine and Biology, Vol. 36, No. 2, pp. 325-335, 2010 (IF=2.645, 7/32 in ¡§Acoustics¡¨). link

64.   Y-C Lin, C-C Wang, Y-Y Wai, Y-L Wan,S-H Ng, Y-L Chen, H-L Liu, J-J Wang, ¡§Significant temporal evolution of diffusion anisotropy for evaluating of early response to radiosurgery in patients with vestibular schwannoma: findings from functional diffusion maps,¡¨ American Journal of Neuroradiology, Vol. 31, pp. 269-274, 2010. (IF=3.55, 24/124 in ¡§Radiology¡¨)

65.   H-L Liu, Y-Y Wai, P-H Hsu, L-A Lyu, J-S Wu, C-R Shen, J-C Chen, T-C Yen, and J-J Wang, ¡§In Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Blood¡Vbrain Barrier with Focused Ultrasound: A Magnetic Resonance Imaging Study,¡¨ Journal of Cerebral Blood Flow & Metabolism, Vol. 30, pp. 168-177, 2010 (IF=5.081, 33/252 in ¡§Neuroscience¡¨). link

66.   J-J Wang, Y-Y Wai, Y-H Weng, K-K Ng, Y-Z Huang; L. Ying, H-L Liu, and C-H Wang, ¡§Functional MRI in the assessment of cortical activation during gait-related imaginary tasks,¡¨ Journal of Neural Transmission, Vol. 116, pp. 1087 ¡V 1092, 2009 (IF=2.402, 125/243 in ¡§Neuroscience¡¨).

67.   H-L Liu, M-L Li, T-C Shih, S-M Huang, I-Y Lu, D-Y Lin, S-M Lin and K-C Ju, "Instantaneous Frequency Based Ultrasonic Temperature Estimation during Focused Ultrasound Thermal Therapy," Ultrasound in Medicine and Biology, Vol. 35, No. 10, pp. 1647-1661, 2009 (IF=2.214, 5/29 in¡§Acoustics¡¨).

68.   K-J Lin**, H-L Liu**, P-H Hsu, Y-H Chung,W-C Huang, J-C Chen, S-P Wey, T-C Yen, I-T Hsiao, ¡§Quantitative microSPECT/CT for detecting focused ultrasound induced blood-brain barrier opening in the rat,¡¨ Nuclear Medicine and Biology, Vol. 36, No. 7, pp. 853-867, 2009 (**¦@¦P²Ä¤@§@ªÌ, IF=2.412, 42/125 in ¡§Radiology¡¨).

69.   H-L Liu and C-M Hsieh, "Single-Transducer Dual-Frequency Ultrasound Generation to Enhance Acoustic Cavitation," Ultrasononics Sonochemistry, Vol. 16, No. 3, pp. 431-438, 2009 (IF=6.012, 1/31 in ¡§Acoustics¡¨).

70.   H-L Liu, P-H Hsu, P-J Ju, Y-Y Wai, J-C Chen, C-R Shen, T-C Yen, and J-J Wang, "Magnetic Resonance Imaging Enhanced by Superparamagnetic Iron Oxide Particles: Usefulness for Distinguishing Between Focused Ultrasound-Induced Blood-Brain Barrier Disruption and Brain Hemorrhage," Journal of Magnetic Resonance Imaging, Vol. 29, No. 1, pp. 31-38, 2009 (IF=3.210, 23/125 in ¡§Radiology¡¨).

71.   H-L Liu, H-W Chen, Z-H Kuo, and W-C Huang, ¡§Design and Experimental Evaluations of a Low-Frequency Hemispherical Ultrasound Phased-Array System for Transcranial Blood-Brain Barrier Disruption¡¨ IEEE Transactions on Biomedical Engineering, Vol.55, No. 10, pp. 2407-2416., 2008 (IF=4.288, 9/78 in ¡§Engineering, Biomedical¡¨).

72.   J-J Wang, Y-C Lin, Y-Y Wai, H-L Liu, C-P Lin, Y-Z Huang, ¡§Visualization of the coherence of the principal diffusion orientation: an eigenvector-based approach,¡¨ Magnetic Resonance in Medicine, Vol. 59, No. 4, pp.764-770, 2008 (IF=3.267, 22/120 in ¡§Radiology¡¨).

73.   H-L Liu, Y-Y Wai, W-S Chen, J-C Chen, P-H Hsu, X-Y W, W-C Huang, T-C Yen, and J-J Wang, ¡§Hemorrhage Detection during Focused-Ultrasound Induced Blood¡VBrain-Barrier Opening by Using Susceptibility-Weighted Magnetic Resonance Imaging,¡¨ Ultrasound in Medicine & Biology, Vol. 34, No. 4, pp. 598-606, 2008 (IF=2.645, 7/32 in ¡§Acoustics¡¨).

74.   T-C Shih, H-L Liu, K-C Ju, C-S Huang, P-Y Chen, H-W Huang, Y-J Ho, ¡§The feasibility of heating on tumor periphery by using high intensity focused ultrasound thermal surgery,¡¨ Int. Comm. Heat Mass Trans., Vol. 35, pp. 439-445, 2008 (IF=2.315, 8/54 in ¡§Thermodynamics¡¨).

75.   H-L Liu, H Chang, W-S Chen, T-C Shih, J-K Hsiao, and W-L Lin, ¡§Feasibility of Transrib Focused Ultrasound Thermal Ablation for Liver Tumors Using a Spherically Curved 2D Array: A Numerical Study,¡¨ Medical Physics, Vol. 34, No. 9, pp. 3436-3448, 2007 (IF=2.884, 36/126 in ¡§Radiology¡¨).

76.   H-L Liu , T-C Shih , W-S Chen and K-C Ju,¡§A Novel Strategy to Increase Heating Efficiency in a Split-Focus Ultrasound Phased Array,¡¨ Medical Physics, Vol. 34, No. 7, pp. 2957-2967, 2007 (IF=2.884, 36/126 in ¡§Radiology¡¨).

77.   H-L Liu, W-L Lin, and Y-Y Chen , ¡§A Fast and Conformal Heating Scheme for Producing Large Thermal Lesions Using a 2-D Ultrasound Phased Array,¡¨ International Journal of Hyperthermia, Vol. 23, No. 1, pp. 69 ¡V 82, 2007 (IF=2.645, 37/125in ¡§Radiology¡¨).

78.   H-L Liu, Y-Y Chen, W-S Chen, T-C Shih, J-S Chen, and W-L Lin, "Interactions between consecutive sonications for characterizing the thermal mechanism in focused ultrasound therapy,¡¨ Ultrasound in Medicine & Biology, Vol. 32, No. 9, pp. 1411 ¡V 1421, 2006 (IF=2.645, 7/32 in ¡§Acoustics¡¨).

79.   Y-S Tung, H-L Liu, C-C Wu, K-C Ju, W-S Chen, and W-L Lin, ¡§Contrast-agent enhanced ultrasound thermal ablation,¡¨ Ultrasound in Medicine & Biology, Vol. 32, No. 7, pp. 1103 ¡V 1110, 2006 (IF=2.645, 7/32 in ¡§Acoustics¡¨).

80.   W-S Chen, C-C Wu, S-Y Fang, H-L Liu* (Corresponding author), ¡§Differences in the lesion formation process between focused ultrasound and microwave ablations,¡¨ Medical Physics, Vol. 33, No. 5, pp. 1346-1351, 2006 (IF=2.884, 36/126 in ¡§Radiology¡¨).

81.   H-L Liu, W-S Chen, J-S Chen, T-C Shih, Y-Y Chen, and W-L Lin, "Cavitation - Enhanced Ultrasound Thermal Therapy by Combined Low- and High-Frequency Ultrasound Exposure,¡¨ Ultrasound in Medicine & Biology, Vol. 32, No. 5, pp. 759-767, 2006 (SCI IF:2.021, 4/31 in¡§Acoustics¡¨).

82.   T-C Shih, H-L Liu, and Allen T-L Horng, ¡§Cooling effect of thermally significant blood vessels in perfused tumor tissue during thermal therapy,¡¨ Int. Comm. Heat Mass Trans., Vol. 33, pp. 135-141, 2006 (IF=2.315, 8/54 in ¡§Thermodynamics¡¨).

83.   W-S Chen, P-M Ma, H-L Liu, C-K Yeh, M-S Chen, and C-W Chang, "A novel method for estimating the focal size of two confocal high-intensity focused ultrasound transducers," J. Acoust. Soc. Am., Vol. 117, No. 6, pp.3740-3749, 2005 (IF=1.646, 9/31 in ¡§Acoustics¡¨).

84.   H-L Liu, Nathan McDannold, and K. Hynynen, ¡§Focal beam distortion and treatment planning in abdominal focused ultrasound surgery,¡¨ Medical Physics, Vol. 32, pp.1270-1280, 2005 (IF=2.884, 36/126 in ¡§Radiology¡¨).

85.   H-L Liu, Y-Y Chen, J-Y Yen and W-L Lin, ¡§A Pilot Point Temperature Regulation for Thermal Dose Control during Ultrasound Thermal Therapy,¡¨ Medical & Biological Engineering & Computing, Vol. 42, pp. 178-188, 2004 (IF=1.791, 33/79 in ¡§Engineering, Biomedical¡¨).

86.   H-L Liu, Y-Y Chen, J-Y Yen, W-L Lin, ¡§Thermal lesion formation and determination in external ultrasound thermal therapy,¡¨ Biomedical Engineering ¡V Applications, Basis, and Communications, Vol. 15, No. 3, pp. 124-132, 2003 (EI ).

87.   H-L Liu, Y-Y Chen, J-Y Yen and W-L Lin, ¡§Treatment time reduction for large thermal lesions by using a multiple 1-d ultrasound phased array system,¡¨ Physics in Medicine and Biology, Vol. 48, pp.1173-1190, 2003 (IF=2.701, 19/79 in ¡§Engineering, Biomedical¡¨).

88.   W-L Lin, T-C Liang, J-Y Yen, H-L Liu and Y-Y Chen, ¡§Optimization of power deposition and a heating strategy for ultrasound thermal therapy,¡¨ Medical Physics, Vol. 28, No. 10, pp. 2172-2181, 2001 (IF=2.884, 36/126 in ¡§Radiology¡¨).

89.   Y-Y Chen, W-L Lin, H-L Liu, J-Y Yen and M-J Shieh, ¡§Self-tuning fuzzy logic control for ultrasound hyperthermia with reference temperature based on objective functions,¡¨ Medical Physics, Vol. 26, No. 5, pp. 825-833, 1999 (IF=2.884, 36/126 in ¡§Radiology¡¨).

 

 (B) Patents

l  H-L Liu, S-F Chen, and H Chang, "Multiple-Frequency Ultrasonic Phased Array Driving System, " EU Patent No. EP2640465, Nov. 7, 2018.

l  H-L Liu, K-C Wei, H-C Tsai, L-Y Lu, " Neuronavigation-guided focused ultrasound system and method thereof," EU Patent No. EP2858619A4, 2018. 

l  H-L Liu, K-C Wei, H-C Tsai, L-Y Lu, " Neuronavigation-guided focused ultrasound system and method thereof," CA Patent No. CN103479403B, 2016.

l  HL Liu, KC Wei, PY Chen, PH Hsu, PC Chu, WY Chai, CY Lin, Method for ultrasound mediated delivery system to monitor molecular penetration, US Patent, 10076652B2, Sept. 18, 2017.

l  HL Liu, MT Tsai, CK Yeh, Imaging devices, systems, and methods of operation for acoustic-enhanced optical coherence tomography, US Patent 15702574, 2018.

l  ¼B¯E¿C¡B½²§»ªN¡B¿c­§¤¯¡BÃQ°ê¬Ã¡A¡§¥H¤â³N¾É¯è¨t²Î¾É¤Þ»EµJ¦¡¶W­µªiÄÀ©ñ¯à¶q¤§¨t²Î¤Î¨ä¤èªk¡A¡¨¿D¬w, 2013271506, 2017.

l  ¼B¯E¿C¡B½²©sÀé¡B¸­¯´¥ú¡AÁn­PÅã¼v¼W±j¥ú¦P½Õ¼v¹³¤§ÃèÀY¤Î¨ä¨t²Î©M¹B§@¤èªk¡A¤¤µØ¥Á°ê(µo©ú),I616690, 2018.

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l  ¼B¯E¿C¡B±i®¤¡B³¯¸t¤Ò¡A¡§½ÆÀW¶W­µªi¬Û¦ì°}¦CÅX°Ê¨t²Î¡¨¡A¤¤µØ¤H¥Á¦@©M°ê(µo©ú), CN103347564B, Sept. 21, 2016.

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l  H-L Liu, W-L Lin, and H Chang, ¡§Medical Treatment using an Ultrasound Phased Array,¡¨ U. S. Patent No. 8,287471, Oct 16, 2012.

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l  H-L Liu, I-Y Lu and S-M Huang, "Method and apparatus for real-time temperature measuring for high-intensity focused ultrasound (HIFU) therapy system," U. S. Patent No. 8,226,559, July 24, 2012.

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l  H-L Liu and Chao-Ming Hsieh, ¡§Multiple frequency driven ultrasound device,¡¨ US Patent No. 7,530,272, May. 12, 2009.

l  ¼B¯E¿C¡B®}¸q²[¡B±Z³Õµ¾¡B¸âµ{³Í,¡§¶W­µªi¤ÀªR¸Ë¸m,¡¨¤¤µØ¥Á°ê(µo©ú),I578693, 2017.

l  ¼B¯E¿C¡BÃQ°ê¬Ã¡B³¯«~¤¸¡B³\³Õªl¡B¦¶§BÂ@¡B®ã¶²¿P¡BªL¤¤­^, ¡§¥H¶W­µªi§@¬°¶Ç»¼´C¤¶¤§ºÊ±±¤À¤l³q³z¶qªº¤èªk,¡¨ ¤¤µØ¥Á°ê(µo©ú) , ±M§Q¸¹I562801, Dec. 12, 2016.

l  ¼B¯E¿C¡B½²¦Ü¬x¡BÃQ°ê¬Ã¡B³¯«~¤¸, ¡§¶W­µªi¦¬µo³B²z¨t²Î¤Î¨ä³B²z¤èªk,¡¨ ¤¤µØ¥Á°ê(µo©ú) , I552730, 10/16, 2016.

l  ¼B¯E¿C¡B¸âµ{³Í, ¤f³U«¬¶W­µªi·Å«×¤ÀªR»ö¤Î¨ä¶q´ú¤èªk¡A¤¤µØ¥Á°ê(µo©ú), I514991, 01/01, 2016.

l  °¨Ä­µØ, ¼B¯E¿C, §d¬ê§Q, ¼B¤Ö³Í, ¼Ð¹vÃĪ«¤§§ëÃĨt²Î¤Î¨ä¾Þ§@¤èªk¡A¤¤µØ¥Á°ê(µo©ú), I491425 , 07/11, 2015

l  ¼B¯E¿C¡B½²§»ªN¡B¿c­§¤¯¡BÃQ°ê¬Ã¡B³¯«~¤¸¡A¥H¤â³N¾É¯è¨t²Î¾É¤Þ»EµJ¦¡¶W­µªiÄÀ©ñ¯à¶q¤§¨t²Î¤Î¨ä¤èªk¡A¤¤µØ¥Á°ê(µo©ú), I488613, 06/21, 2015

l  ¼B¯E¿C¡AªL«T¦w¡A¶W­µªi§Y®É¥\率ºÊ±±¨t²Î¡A¤¤µØ¥Á°ê(µo©ú), ±M§Q¸¹I489802, June 21, 2015.

l  µØ¨N©É¡B¼B¯E¿C¡B·¨¶£½«¡BÃQ°ê¬Ã¡B³¯«~¤¸¡B½²ºa·½¡A¨ã¦³¦h­«¤ÏÀ³©Ê©x¯à°ò¤§ºÏ©Ê©`¦Ì²É¤l½Æ¦Xª«¤Î¨ä»s³Æ¤èªk¡A¤¤µØ¥Á°ê(µo©ú), I445550, 7/21¡A2014.

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l  ¼B¯E¿C¡B³¯¸t¤Ò¡B±i®¤¡A½ÆÀW¶W­µªi¬Û¦ì°}¦CÅX°Ê¨t²Î, ¤¤µØ¥Á°ê(µo©ú), ±M§Q¸¹I426245, Feb. 11, 2014.

l  ¼B¯E¿C¡BÅDZR¸Û¡B±i®x¹Å¡A¤@ºØ¥ú¾Ç¦¡¶W­µªiÆ[´ú¸Ë¸m¤Î¨ä©µ¿ð¦P¨B±±¨îªº¤èªk¡A¤¤µØ¥Á°ê(µo©ú), ±M§Q¸¹I409452, Sept. 21, 2013.

l  ¼B¯E¿C¡B¿c«³¾ç¡B¶À¸t¶{, «D«I¤J¦¡¶W­µªi§Y®É·Å«×¶q´ú¸Ë¸m¤Î¨ä¤èªk, ¤¤µØ¥Á°ê(µo©ú), ±M§Q¸¹I406684, Sept. 1, 2013, 2013.

l  ¼B¯E¿C¡B¶À¤å¥¿, «D«I¤J¦¡§CÀW¶W­µªi¸£³¡ªvÀø¸Ë¸m, ¤¤µØ¥Á°ê(µo©ú), ¥Ó½Ð¸¹, ±M§Q¸¹I382860, Jan. 21, 2013.

l  ¼B¯E¿C¡BªL¤å¿C¡B±i®¤, ¡§¤@ºØ¥H¶W­µªi¬Û¦ì°}¦C¹F¨ì¬ï³z¦Ø°©ªvÀø¤§¨t²Î¤Î¤èªk, ¤¤µØ¥Á°ê(µo©ú),¡¨ ±M§Q¸¹I377076, Nov. 21, 2012.

l  ¼B¯E¿C¡B³¯¤åµ¾¡B¸âµ{³Í,"¤@ºØ§Îª¬°O¾Ð¦Xª÷ªº±±¨î¾¹¸Ë¸m©M±±¨î¤èªk,¡¨ ¤¤µØ¥Á°ê(µo©ú), ±M§Q¸¹I367410, July 1, 2012.

l  ³¯¤åµ¾¡B¼B¯E¿C¡B¶À«Û´É¡B°¨¼C²M¡B½²°¶³Õ¡B¬I¤å±l¡BÀ¹¤l¦w¡A¡§¤H¤u¬A¬ù¦Ù¨t²Î,¡¨ ¤¤µØ¥Á°ê(µo©ú), ±M§Q¸¹I351271, Nov. 11, 2011.

l  ¼B¯E¿C¡BÁÂ¥ü»ï, ¡§¦hÀWÅX°Ê³æ¤@´«¯à¾¹¤§¶W­µªi¨t²Î¤Î°T¸¹²£¥Í¸Ë¸m¡¨, ¤¤µØ¥Á°ê(µo©ú), ±M§Q¸¹I323196, April 11, 2010.

l  ¼B¯E¿C¡B³¢Âí»¨¡B³¯«í¤å¡A¡§¥Íª«ÂåÀø¥Î¥b¶êÀY¸n¦¡¶W­µªi¬Û¦ì°}¦C¸Ë¸m,¡¨ ¤¤µØ¥Á°ê(µo©ú), ±M§Q¸¹I337087, Feb. 11, 2011.